Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.

ABSTRACT: Ewing sarcoma (ES) is a malignant pediatric bone and soft tissue tumor. Patients with metastatic ES have a dismal outcome which has not been improved in decades. The major challenge in the treatment of metastatic ES is the lack of specific targets and rational combinatorial therapy. We recently found that protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is specifically highly expressed in ES and promotes tumor growth and metastasis in ES. In the current investigation, we show that PPP1R1A regulates ES cell cycle progression in G1/S phase by down-regulating cell cycle inhibitors p21^Cip1 and p27^Kip1, which leads to retinoblastoma (Rb) protein hyperphosphorylation. In addition, we show that PPP1R1A promotes normal transcription of histone genes during cell cycle pro

SUBMITTER: Luo W 

PROVIDER: S-EPMC7233808 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature