GDF15 mediates the effects of metformin on body weight and energy balance.

ABSTRACT: Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk^1,2. More than 60% of this effect is attributable to the ability of metformin to lower body weight in a sustained manner³. The molecular mechanisms by which metformin lowers body weight are unknown. Here we show-in two independent randomized controlled clinical trials-that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor. In wild-type mice, oral metformin increased circulating GDF15, with GDF15 expression increasing predominantly in the distal intestine and the kidney. Metformin prev

SUBMITTER: Coll AP 

PROVIDER: S-EPMC7234839 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature