Coordination difficulties, IQ and psychopathology in children with high-risk copy number variants.

ABSTRACT:

Background

The prevalence and impact of motor coordination difficulties in children with copy number variants associated with neurodevelopmental disorders (ND-CNVs) remains unknown. This study aims to advance understanding of motor coordination difficulties in children with ND-CNVs and establish relationships between intelligence quotient (IQ) and psychopathology.

Methods

169 children with an ND-CNV (67% male, median age = 8.88 years, range 6.02-14.81) and 72 closest-in-age unaffected siblings (controls; 55% male, median age = 10.41 years, s.d. = 3.04, range 5.89-14.75) were assessed with the Developmental Coordination Disorder Questionnaire, alongside psychiatric interviews and standardised assessments of IQ.

Results

The children with ND-CNVs had poorer coordination

SUBMITTER: Cunningham AC 

PROVIDER: S-EPMC7234895 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature