Early exposure to antibiotics in the neonatal intensive care unit alters the taxonomic and functional infant gut microbiome.

ABSTRACT:

Introduction

The infant gut microbiome is thought to play a key role in developing metabolic and immunologic pathways. Antibiotics have been shown to disrupt the human microbiome, but the impact they have on infants during this key window of development remains poorly understood. Through this study, we further characterize the effect antibiotics have on the gut microbiome of infants by looking at metagenomic sequencing data over time.

Materials and methods

Stool samples were collected on infants from a large tertiary care neonatal intensive care unit. After DNA extraction, metagenomics libraries were generated and sequenced. Taxonomic and functional analyses were then performed. Further directed specimen sequencing for fungal species was also performed.

Results

A tota

SUBMITTER: Bender JM 

PROVIDER: S-EPMC7234909 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature