Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug.

ABSTRACT:

Purpose

The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan cilexetil.

Methods

To achieve this target, various techniques were employed such as solid dispersions, inclusion complexes, and preparation of candesartan nanoparticles. Following the preparations, all samples were characterized for their physicochemical properties, and the samples of the best results were subjected to further bioavailability studies.

Results

Results of dissolution studies revealed an increase in the dissolution rate of all samples. The highest dissolution rate was achieved using solid dispersion of the drug with PVP K-90 (1:4). Physicochemical investigations (XR, DSC, and FT-IR) suggested

SUBMITTER: Aly UF 

PROVIDER: S-EPMC7234962 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature