Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure.

ABSTRACT: In heart failure, myocardial overload causes vast metabolic changes that impair cardiac energy production and contribute to deterioration of contractile function. However, metabolic therapy is not used in heart failure care. We aimed to investigate the interplay between cardiac function and myocardial carbohydrate metabolism in a large animal heart failure model. Using magnetic resonance spectroscopy with hyperpolarized pyruvate and magnetic resonance imaging at rest and during pharmacological stress, we investigated the in-vivo cardiac pyruvate metabolism and contractility in a porcine model of chronic pulmonary insufficiency causing right ventricular volume overload. To assess if increasing the carbohydrate metabolic reserve improves the contractile reserve, a group of animals were fed d

SUBMITTER: Bogh N 

PROVIDER: S-EPMC7235019 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature