Ontology highlight
ABSTRACT:
SUBMITTER: Pastore N
PROVIDER: S-EPMC7235048 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pastore Nunzia N Huynh Tuong T Herz Niculin J NJ Calcagni' Alessia A Klisch Tiemo J TJ Brunetti Lorenzo L Kim Kangho Ho KH De Giorgi Marco M Hurley Ayrea A Carissimo Annamaria A Mutarelli Margherita M Aleksieva Niya N D'Orsi Luca L Lagor William R WR Moore David D DD Settembre Carmine C Finegold Milton J MJ Forbes Stuart J SJ Ballabio Andrea A
Nature communications 20200518 1
It is well established that pluripotent stem cells in fetal and postnatal liver (LPCs) can differentiate into both hepatocytes and cholangiocytes. However, the signaling pathways implicated in the differentiation of LPCs are still incompletely understood. Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is known to be involved in osteoblast and myeloid differentiation, but its role in lineage commitment in the liver has not been investigated. Here we show ...[more]