Integration analysis of methylation quantitative trait loci and GWAS identify three schizophrenia risk variants.

ABSTRACT: Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with schizophrenia (SCZ). However, prioritizing risk variants and regulatory elements for follow-up functional studies remains a major challenge. Therefore, we performed an integrated analysis to identify variants who affect methylation levels of nearby genes and contribute to the risk of SCZ, and to explore the potential role of these variants in SCZ pathogenesis. First, we used the Summary data-based Mendelian Randomization (SMR) method to integrate GWAS and methylation quantitative trait loci data. Then, the SNP-methylation combinations as associated with SCZ were replicated across multiple samples. Totally, we identified and replicated 14 and one SNP-methylation combinations in blood and brai

SUBMITTER: Yu H 

PROVIDER: S-EPMC7235211 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature