Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan.

ABSTRACT: Dysregulation of the gut microbiome is associated with dementia. However, the relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled in this cross-sectional study; 107 subjects were eligible for the study, 25 of which had dementia. We collected demographics, activities of daily living, risk factors, cognitive function, and brain imaging data. The gut microbiome was assessed using terminal restriction fragment length polymorphism analysis. Concentrations of faecal metabolite were measured. We used multivariable logistic regression analyses to identify whether metabolites were independently related to dementia. The concentrations of metabolites were significantly different between subjects with and

SUBMITTER: Saji N 

PROVIDER: S-EPMC7235213 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature