Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.

ABSTRACT: Neurobehavioral studies have produced contradictory findings concerning the function of neurogenesis in the adult dentate gyrus. Previous studies have proved inconsistent across several behavioral endpoints thought to be dependent on dentate neurogenesis, including memory acquisition, short-term and long-term retention of memory, pattern separation, and reversal learning. We hypothesized that the main function of dentate neurogenesis is long-term memory formation because we assumed that a newly formed and integrated neuron would have a long-term impact on the local neural network. We used a cyclin D2-knock-out (cyclin D2^-/-) mouse model of endogenously deficient dentate neurogenesis to test this hypothesis. We found that cyclin D2^-/- mice had robust and sustained loss

SUBMITTER: Petkova SP 

PROVIDER: S-EPMC7235216 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature