Ontology highlight
ABSTRACT:
SUBMITTER: Johnson EL
PROVIDER: S-EPMC7235224 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200518 1
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic steatosis. SLs are obtained from the diet and generated by de novo synthesis in mammalian tissues. Another potential, but unexplored, source of mammalian SLs is production by Bacteroidetes, the dominant phylum of the gut microbiome. Genomes of Bacteroide ...[more]