Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach.

ABSTRACT: Metastasis is the cause of over 90% of cancer-related deaths. Cancer cells undergoing metastasis can switch dynamically between different phenotypes, enabling them to adapt to harsh challenges, such as overcoming anoikis and evading immune response. This ability, known as phenotypic plasticity, is crucial for the survival of cancer cells during metastasis, as well as acquiring therapy resistance. Various biochemical networks have been identified to contribute to phenotypic plasticity, but how plasticity emerges from the dynamics of these networks remains elusive. Here, we investigated the dynamics of various regulatory networks implicated in Epithelial-mesenchymal plasticity (EMP)-an important arm of phenotypic plasticity-through two different mathematical modelling frameworks: a discrete,

SUBMITTER: Hari K 

PROVIDER: S-EPMC7235229 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature