Emerging Roles of Activity-Dependent Alternative Splicing in Homeostatic Plasticity.

ABSTRACT: Homeostatic plasticity refers to the ability of neuronal networks to stabilize their activity in the face of external perturbations. Most forms of homeostatic plasticity ultimately depend on changes in the expression or activity of ion channels and synaptic proteins, which may occur at the gene, transcript, or protein level. The most extensively investigated homeostatic mechanisms entail adaptations in protein function or localization following activity-dependent posttranslational modifications. Numerous studies have also highlighted how homeostatic plasticity can be achieved by adjusting local protein translation at synapses or transcription of specific genes in the nucleus. In comparison, little attention has been devoted to whether and how alternative splicing (AS) of pre-mRNAs underlie

SUBMITTER: Thalhammer A 

PROVIDER: S-EPMC7235277 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature