Compensatory Cross-Modal Plasticity Persists After Sight Restoration.

ABSTRACT: Sensory deprivation prompts extensive structural and functional reorganizations of the cortex resulting in the occupation of space for the lost sense by the intact sensory systems. This process, known as cross-modal plasticity, has been widely studied in individuals with vision or hearing loss. However, little is known on the neuroplastic changes in restoring the deprived sense. Some reports consider the cross-modal functionality maladaptive to the return of the original sense, and others view this as a critical process in maintaining the neurons of the deprived sense active and operational. These controversial views have been challenged in both auditory and vision restoration reports for decades. Recently with the approval of Luxturna as the first retinal gene therapy (GT) drug to reverse

SUBMITTER: Mowad TG 

PROVIDER: S-EPMC7235304 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature