Identification of Novel Molecular Network Expression in Acute Myocardial Infarction.

ABSTRACT:

Background

In the current study, we aimed to analyze the hypothesis that human myocardial-specific extracellular RNAs expression could be used for acute myocardial injury(AMI) diagnosis.

Methodology

We used bioinformatics' analysis to identify RNAs linked to ubiquitin system and specific to AMI, named, (lncRNA-RP11-175K6.1), (LOC101927740), microRNA-106b-5p (miR-106b-5p) and Anaphase, promoting complex 11 (ANapc11mRNA). We measured the serum expression of the chosen RNAs in 69 individuals with acute coronary syndromes, 31 individuals with angina pectoris without MI and non-cardiac chest pain and 31 healthy control individuals by real-time reverse-transcription PCR.

Results

Our study revealed a significant decrease in both lncRNA-RP11-175K6.1 and ANapc

SUBMITTER: Matboli M 

PROVIDER: S-EPMC7235391 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature