Genetic polymorphism of merozoite surface protein-3 in Myanmar Plasmodium falciparum field isolates.

ABSTRACT:

Background

Plasmodium falciparum merozoite surface protein-3 (PfMSP-3) is a target of naturally acquired immunity against P. falciparum infection and is a promising vaccine candidate because of its critical role in the erythrocyte invasion of the parasite. Understanding the genetic diversity of pfmsp-3 is important for recognizing genetic nature and evolutionary aspect of the gene in the natural P. falciparum population and for designing an effective vaccine based on the antigen.

Methods

Blood samples collected from P. falciparum-infected patients in Naung Cho and Pyin Oo Lwin, Myanmar, in 2015 were used in this study. The pfmsp-3 was amplified by polymerase chain reaction, cloned, and sequenced. Genetic polymorphism and natural selection of Myanmar pfmsp-3 were analysed usi

SUBMITTER: Le HG 

PROVIDER: S-EPMC7235555 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature