Validation of Predictors of Disease Severity and Outcomes in COVID-19 Patients: A Descriptive and Retrospective Study.

ABSTRACT:

Background

The severity and outcome of COVID-19 cases has been associated with the percentage of circulating lymphocytes (LYM%), levels of C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), lactic acid (LA), and viral load (ORF1ab Ct). However, the predictive power of each of these indicators in disease classification and prognosis remains largely unclear.

Methods

We retrospectively collected information on the above parameters in 142 patients with COVID-19, stratifying them by survival or disease severity.

Findings

CRP, PCT, IL-6, LYM%, and ORF1ab Ct were significantly altered between survivors and non-survivors. LYM%, CRP, and IL-6 were the most sensitive and reliable factors in distinguishing between survivors and non-survivors. These indicators w

SUBMITTER: Tan L 

PROVIDER: S-EPMC7235581 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature