Fasting glucose variability in young adulthood and incident diabetes, cardiovascular disease and all-cause mortality.

ABSTRACT:

Aims/hypothesis

The aim of this study was to determine whether long-term intra-individual variability in fasting glucose (FG) during young adulthood is associated with incident diabetes, cardiovascular disease (CVD) and mortality.

Methods

We included participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study, ages 18-30 years at baseline (1985-1986) and followed with eight examinations for up to 30 years. Long-term glucose variability was assessed using the CV (CV-FG) and the absolute difference between successive FG measurements (average real variability; ARV-FG). For participants who developed any event (diabetes, CVD or mortality), FG variability measurement was censored at the examination prior to event ascertainment. We estimated HRs for incid

SUBMITTER: Bancks MP 

PROVIDER: S-EPMC7235631 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature