Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly.

ABSTRACT: Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O₂ max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexes are large respiratory assemblies of individual electron transport chain complexes which can promote more efficient respiration. In this study, we examined pulmonary hypertension and exercise-induced changes in skeletal muscle electron transport chain protein expression and supercomplex assembly. Pulmonary arterial hypertension was induced in rats with the Sugen/Hypoxia model (10% FiO₂, three weeks). Pulmonary arterial hypertension and control rats were assigned to an exercise training protocol group or kept sedentary for o

SUBMITTER: McCullough DJ 

PROVIDER: S-EPMC7235683 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature