Apoptosis signal-regulating kinase 1 inhibition in <i>in vivo</i> and <i>in vitro</i> models of pulmonary hypertension.

ABSTRACT: Pulmonary arterial hypertension, group 1 of the pulmonary hypertension disease family, involves pulmonary vascular remodelling, right ventricular dysfunction and cardiac failure. Oxidative stress, through activation of mitogen-activated protein kinases is implicated in these changes. Inhibition of apoptosis signal-regulating kinase 1, an apical mitogen-activated protein kinase, prevented pulmonary arterial hypertension developing in rodent models. Here, we investigate apoptosis signal-regulating kinase 1 in pulmonary arterial hypertension by examining the impact that its inhibition has on the molecular and cellular signalling in established disease. Apoptosis signal-regulating kinase 1 inhibition was investigated in in vivo pulmonary arterial hypertension and in vitro pulmona

SUBMITTER: Wilson KS 

PROVIDER: S-EPMC7235684 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature