Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives.

ABSTRACT: The aim of the work is to study the metabolic characteristics of saliva in lung cancer for use in early diagnosis and determining the prognosis of the disease. The patient group included 425 lung cancer patients, 168 patients with non-cancerous lung diseases, and 550 healthy volunteers. Saliva samples were collected from all participants in the experiment before treatment and 34 biochemical saliva parameters were determined. Participants were monitored for six years to assess survival rates. The statistical analysis was performed by means of Statistica 10.0 (StatSoft) program and R package (version 3.2.3). To construct the classifier, the Random Forest method was used; the classification quality was assessed using the cross-validation method. Prognostic factors were analyzed by multivariat

SUBMITTER: Bel'skaya LV 

PROVIDER: S-EPMC7235830 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature