Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events.

ABSTRACT:

Importance

Tumor necrosis factor (TNF) inhibitors are common therapies for certain autoimmune diseases, such as rheumatoid arthritis. An association between TNF inhibitor exposure and inflammatory central nervous system (CNS) events has been postulated but is poorly understood.

Objective

To evaluate whether TNF inhibitor exposure is associated with inflammatory demyelinating and nondemyelinating CNS events in patients with an indication for TNF inhibitor use and to describe the spectrum of those CNS events.

Design, setting, and participants

A nested case-control study was conducted using the medical records of patients with autoimmune diseases treated at 3 Mayo Clinic locations (Rochester, Minnesota; Scottsdale, Arizona; and Jacksonville, Florida) between January 1, 2

SUBMITTER: Kunchok A 

PROVIDER: S-EPMC7235930 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature