Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development.

ABSTRACT: The coordination of growth during development establishes proportionality within and among the different anatomic structures of organisms. Innate memory of this proportionality is preserved, as shown in the ability of regenerating structures to return to their original size. Although the regulation of this coordination is incompletely understood, mutant analyses of zebrafish with long-finned phenotypes have uncovered important roles for bioelectric signaling in modulating growth and size of the fins and barbs. To date, long-finned mutants identified are caused by hypermorphic mutations, leaving unresolved whether such signaling is required for normal development. We isolated a new zebrafish mutant, schleier, with proportional overgrowth phenotypes caused by a missense mutation and loss of

SUBMITTER: Lanni JS 

PROVIDER: S-EPMC7235970 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature