Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand.

ABSTRACT: A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N₄-tetradentate binding pocket [Pt(L)]Cl₂·2H₂O (Complex 1) was synthesized and characterized by FT-IR(ATR), UV-vis, ¹H NMR, APCI and MALDI MS, and CHN analysis. The antigrowth effect of Complex 1 was tested in breast cancer (MDA-MB-231), lung cancer (A549), colorectal cancer (HCT-116), prostate cancer (PC-3) cell lines, and bronchial epithelial cell line (BEAS-2B) by the SRB and ATP cell viability assays. Apoptosis was detected with Annexin V, mitopotential, BCL-2 inactivation, and γH2AX assays by flow cytometry. Complex 1 was found to have cytotoxic activity of MDA-MB-231, A549, HC

SUBMITTER: Yılmaz I 

PROVIDER: S-EPMC7236228 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature