Evaluation of neurapheresis therapy in vitro: a novel approach for the treatment of leptomeningeal metastases.

ABSTRACT:

Background

Leptomeningeal metastases (LM), late-stage cancer when malignant cells migrate to the subarachnoid space (SAS), have an extremely poor prognosis. Current treatment regimens fall short in effectively reducing SAS tumor burden. Neurapheresis therapy is a novel approach employing filtration and enhanced circulation of the cerebrospinal fluid (CSF). Here, we examine the in vitro use of neurapheresis therapy as a novel, adjunctive treatment option for LM by filtering cells and augmenting the distribution of drugs that may have the potential to enhance the current clinical approach.

Methods

Clinically relevant concentrations of VX2 carcinoma cells were suspended in artificial CSF. The neurapheresis system's ability to clear VX2 carcinoma cells was tested with and withou

SUBMITTER: Ejikeme T 

PROVIDER: S-EPMC7236387 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature