Viral metagenomic analysis of fecal samples reveals an enteric virome signature in irritable bowel syndrome.

ABSTRACT:

Background

Changes in the enteric microbiota have been suggested to contribute to gastrointestinal diseases, including irritable bowel syndrome. Most of the published work is on bacterial dysbiosis with meager data on the role of the virome in irritable bowel syndrome and other gastrointestinal diseases. In the current study, we therefore aimed to investigate the viral community composition of the gut and test for potential dysbiosis linked to irritable bowel syndrome.

Results

A metagenomics analysis on fecal samples of 50 individuals - 30 of whom met the Rome IV criteria for IBS and 20 healthy controls- was conducted. There was a noticeable alteration in viral taxa observed in association with irritable bowel syndrome when compared to healthy individuals - where some eukary

SUBMITTER: Ansari MH 

PROVIDER: S-EPMC7236503 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature