Age-related differences in white matter diffusion measures in autism spectrum condition.

ABSTRACT:

Background

Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are heterogeneous and vary across the age range of study participants and varying methodological approaches. To characterize the neurodevelopmental trajectory of white matter maturation, it is necessary to examine a broad age range of individuals on the autism spectrum and typically developing controls, and investigate age × group interactions.

Methods

Here, we employed a spatially unbiased tract-based spatial statistics (TBSS) approach to examine age-related differences in white matter connectivity in a sample of 41 individuals with ASC, and 41 matched controls be

SUBMITTER: Thompson A 

PROVIDER: S-EPMC7236504 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature