Ontology highlight
ABSTRACT:
SUBMITTER: Botta L
PROVIDER: S-EPMC7236541 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Botta Lorenzo L Filippi Silvia S Zippilli Claudio C Cesarini Silvia S Bizzarri Bruno Mattia BM Cirigliano Angela A Rinaldi Teresa T Paiardini Alessandro A Fiorucci Diego D Saladino Raffaele R Negri Rodolfo R Benedetti Pietro P
ACS medicinal chemistry letters 20200410 5
Artesunic acid and artemisinin are natural substances with promiscuous anticancer activity against different types of cancer cell lines. The mechanism of action of these compounds is associated with the formation of reactive radical species by cleavage of the sesquiterpene pharmacophore endoperoxide bridge. Here we suggested topoisomerase 1 as a possible molecular target for the improvement of the anticancer activity of these compounds. In this context, we report that novel hybrid and dimer deri ...[more]