The Impact of Obesity On Insulin Sensitivity and Secretion During Pubertal Progression: A Longitudinal Study.

ABSTRACT: Physiologic changes in glucose metabolism are well-described to occur during puberty. However, there are important gaps in understanding the interaction between obesity and the normal physiologic changes during puberty, as well as how these changes could contribute to the increased risk of comorbidities, such as type 2 diabetes and dyslipidemia, in youth with obesity. The objective of this study was to compare longitudinal changes in insulin sensitivity (Si) and secretion during pubertal progression in youth with obesity versus those with normal weight. Longitudinal observational study evaluating youth from early puberty (Tanner [T]2-T3) until puberty completion (T5). Pediatric academic hospital Clinical Translational Research Center. Pubertal youth with normal weight (n = 47; 22 female, 2

SUBMITTER: Kelsey MM 

PROVIDER: S-EPMC7236627 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature