Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review.

ABSTRACT:

Background

Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. With the availability of a new typhoid conjugate vaccine licensed for children and recommended by the World Health Organization, understanding severe complications, including associated mortality rates, is essential to inform country-level decisions on introduction of this vaccine. This scoping review summarizes over 20 years of the literature on typhoid intestinal perforation in sub-Saharan Africa.

Methods

We searched EMBASE, PubMed, Medline, and Cochrane databases for studies reporting mortality rates due

SUBMITTER: Birkhold M 

PROVIDER: S-EPMC7236653 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature