Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series.

ABSTRACT:

Introduction

Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective pharmacodynamic parameters are generally lacking. By integrating continuous physiological data with model-based drug exposure and data on adverse drug reactions (ADRs), we aimed to show the potential benefit for optimized individual pharmacotherapy.

Materials and methods

Continuous data on oxygen saturation (SpO₂), fraction of inspired oxygen (FiO₂) and composite parameters, including the SpO₂/FiO₂ ratio and the cumulative oxygen shortage und

SUBMITTER: Poppe JA 

PROVIDER: S-EPMC7236770 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature