Urinary Estrogen Metabolites and Long-Term Mortality Following Breast Cancer.

ABSTRACT:

Background

Estrogen metabolite concentrations of 2-hydroxyestrone (2-OHE₁) and 16-hydroxyestrone (16-OHE₁) may be associated with breast carcinogenesis. However, no study has investigated their possible impact on mortality after breast cancer.

Methods

This population-based study was initiated in 1996-1997 with spot urine samples obtained shortly after diagnosis (mean = 96 days) from 683 women newly diagnosed with first primary breast cancer and 434 age-matched women without breast cancer. We measured urinary concentrations of 2-OHE₁ and 16-OHE₁ using an enzyme-linked immunoassay. Vital status was determined via the National Death Index (n = 244 deaths after a median of 17.7 years of follow-up). We used multivariable-adjusted Cox pr

SUBMITTER: Wang T 

PROVIDER: S-EPMC7236781 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature