Behavioral Flexibility in Alcohol-Drinking Monkeys: The Morning After.

ABSTRACT:

Background

Heavy alcohol drinking has aspects of inflexible behavior. This study addressed the consequences of chronic alcohol drinking on cognitive and sensory-motor domains of behavioral flexibility in rhesus monkeys.

Methods

Behavioral flexibility was assessed in 12 monkeys (n = 9, ethanol [EtOH] drinkers) with a set-shifting visual discrimination procedure before alcohol self-administration and while maintaining consumption of 1.5 g/kg/d EtOH. Task performance was assessed in the morning after ~18 hours of drinking 1.5 g/kg, and 1 hour before the next day's drinking session began. The first 10 set-shifting sessions had the original (preethanol) test parameters and were used to determine retention of preethanol performance. Then, an effect of sensory-motor challenge (60%

SUBMITTER: Shnitko TA 

PROVIDER: S-EPMC7236888 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature