Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study.

ABSTRACT:

Background

Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive statins. This study sought to understand the association between statin exposure and lung cancer risk in a population-based cohort of COPD patients.

Methods

We identified a population-based cohort of COPD patients based on having filled at least three prescriptions for an anticholinergic or short-acting beta-agonist (SABA). We used an array of methods of defining medication exposure including three conventional methods (ever statin exposure, cumulative duration of use, and cumulative dose) and two novel methods (recency-weighted cumulative duration of use and recency-

SUBMITTER: Raymakers A 

PROVIDER: S-EPMC7236956 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature