Nebulized Poractant Alfa Reduces the Risk of Respiratory Failure at 72 Hours in Spontaneously Breathing Surfactant-Deficient Newborn Piglets.

ABSTRACT:

Objectives

We have setup for the first time a long-term (72 hr) respiratory distress syndrome model in spontaneously breathing surfactant-deficient newborn piglets to investigate the continuous positive airway pressure failure rate with nebulized poractant alfa compared with that with the intubation surfactant extubation technique or continuous positive airway pressure only.

Design

Prospective randomized animal study.

Setting

Biocruces-Bizkaia Health Research Institute Animal Facility.

Subjects-interventions

Eighteen newborn piglets (n = 6/group) with surfactant-deficient respiratory distress syndrome were randomized to three continuous positive airway pressure-ventilated groups: 1) nebulized surfactant (poractant alfa 400 mg/kg) via a customized investigationa

SUBMITTER: Rey-Santano C 

PROVIDER: S-EPMC7237025 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature