Genomic analysis of natural intra-specific hybrids among Ethiopian isolates of Leishmania donovani.

ABSTRACT: Parasites of the genus Leishmania (Kinetoplastida: Trypanosomatidae) cause widespread and devastating human diseases. Visceral leishmaniasis due to Leishmania donovani is endemic in Ethiopia where it has also been responsible for major epidemics. The presence of hybrid genotypes has been widely reported in surveys of natural populations, genetic variation reported in a number of Leishmania species, and the extant capacity for genetic exchange demonstrated in laboratory experiments. However, patterns of recombination and the evolutionary history of admixture that produced these hybrid populations remain unclear. Here, we use whole-genome sequence data to investigate Ethiopian L. donovani isolates previously characterized as hybrids by microsatellite and multi-locus sequencing. To date there

SUBMITTER: Cotton JA 

PROVIDER: S-EPMC7237039 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature