Ex vivo isolated human vessel perfusion system for the design and assessment of nanomedicines targeted to the endothelium.

ABSTRACT: Endothelial cells play a central role in the process of inflammation. Their biologic relevance, as well as their accessibility to IV injected therapeutics, make them a strong candidate for treatment with molecularly-targeted nanomedicines. Typically, the properties of targeted nanomedicines are first optimized in vitro in cell culture and then in vivo in rodent models. While cultured cells are readily available for study, results obtained from isolated cells can lack relevance to more complex in vivo environments. On the other hand, the quantitative assays needed to determine the impact of nanoparticle design on targeting efficacy are difficult to perform in animal models. Moreover, results from animal models often translate poorly to human systems. To address the need for an improved test

SUBMITTER: Lysyy T 

PROVIDER: S-EPMC7237142 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature