Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration.

ABSTRACT: Malignant gliomas are the most common and aggressive form of primary brain tumors, with a median survival of 15-20 months for patients receiving maximal interventions. Advances in nanomedicine have provided tumor-specific delivery of chemotherapeutics to potentially overcome their off-target toxicities. Recent advances in dendrimer-based nanomedicines have established that hydroxyl-terminated poly(amidoamine) dendrimers can intrinsically target neuroinflammation and brain tumors from systemic administration without the need for targeting moieties. The size of nanocarriers is a critical parameter that determines their tumor-targeting efficiency, intratumor distribution, and clearance mechanism. In this study, we explore the dendrimer size effects on brain tumor targeting capability in two c

SUBMITTER: Liaw K 

PROVIDER: S-EPMC7237147 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature