Transcriptional profiling of human macrophages during infection with <i>Bordetella pertussis</i>.

ABSTRACT: Bordetella pertussis, a strictly human re-emerging pathogen and the causative agent of whooping cough, exploits a broad variety of virulence factors to establish efficient infection. Here, we used RNA sequencing to analyse the changes in gene expression profiles of human THP-1 macrophages resulting from B. pertussis infection. In parallel, we attempted to determine the changes in intracellular B. pertussis-specific transcriptomic profiles resulting from interaction with macrophages. Our analysis revealed that global gene expression profiles in THP-1 macrophages are extensively rewired 6 h post-infection. Among the highly expressed genes, we identified those encoding cytokines, chemokines, and transcription regulators involved in the induction of the M1 and M2 macrophag

SUBMITTER: Petrackova D 

PROVIDER: S-EPMC7237194 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature