A major role for common genetic variation in anxiety disorders.

ABSTRACT: Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n_case = 25 453, n_control = 58 113) and an additional analysis of Current Anxiety Symptoms (n_case = 19 012, n_control = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary ar

SUBMITTER: Purves KL 

PROVIDER: S-EPMC7237282 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature