Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study.

ABSTRACT: While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structur

SUBMITTER: Chye Y 

PROVIDER: S-EPMC7237314 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature