Ontology highlight
ABSTRACT:
SUBMITTER: Jewer M
PROVIDER: S-EPMC7237473 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200519 1
Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast cancer cells NANOG, SNAIL and NODAL transcripts manifest multiple isoforms characterized by different 5' Untranslated Regions (5'UTRs), whereby translation of a subset of these isoforms is stimulated under hypoxia. The accumulation of the corresponding proteins induces plasticity and "fate-switching" toward stem ...[more]