Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid.

ABSTRACT:

Purpose

Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation.

Methods

Blood samples of twelve healthy males (mean age and weight: 23.5 ± 3.2 years; 77.5 ± 7.5 kg) were collected before (T₀), immediately after (T₁), and 1 h after completion (T₂) of HYP (5 sets with 10 repetitions at 80% of 1RM) and MAX (15 sets with 1RM) loadings performed in a randomized c

SUBMITTER: Joisten N 

PROVIDER: S-EPMC7237519 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature