Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family.

ABSTRACT:

Purpose of review

Pathogenesis-related class 10 (PR-10) proteins are highly conserved plant proteins, which are induced in response to abiotic and biotic stress factors. To date, no unique biological function could be assigned to them. Rather a more general role of PR-10 in plant development and defense mechanisms has been proposed. In addition, some PR-10 proteins act as allergens by triggering allergic symptoms in sensitized individuals. Regardless of the diversity of reported activities, all PR-10 proteins share a common fold characterized by a solvent-accessible hydrophobic cavity, which serves as a binding site for a myriad of small-molecule ligands, mostly phytohormones and flavonoids.

Recent findings

Most of available data relate to the ligand binding activity of alle

SUBMITTER: Aglas L 

PROVIDER: S-EPMC7237532 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature