Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis.

ABSTRACT: BACKGROUND:Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicrobial therapy might however, also negatively impact the prognosis. The usefulness of sepsis markers in diabetic ketoacidosis has not been assessed. Thus, we sought to investigate diagnostic performances of clinical and biological sepsis markers during diabetic ketoacidosis. METHODS:In this monocentric retrospective cohort study, all consecutive episodes of diabetic ketoacidosis (defined as pH ≤ 7.25, glycaemia > 300 mg/dL and presence of ketones) admitted in intensive care unit were included. A proven bacterial infection was defined as bacteriological documentation on any ba

SUBMITTER: Blanchard F 

PROVIDER: S-EPMC7237630 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature