Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing.

ABSTRACT: Skeletal muscle exhibits enormous plasticity throughout life, however, less is known regarding how the stages of growth regulate its local vitamin D system. Herein, we investigated serum 25(OH)D₃ and Ca²⁺ levels along with the vitamin D system in skeletal muscle and resident myogenic stem cells of male C57BL/6 mice during development, maturation, and ageing. Compared with development, significant increases in vitamin D receptor (VDR) protein expression in mature and aged muscles were associated with increased serum 25(OH)D₃ and centronucleated fibres, respectively. The substantial increase in VDR protein expression in aged muscle was also related to reduced downstream mTOR signalling protein expression which was more pronounced in fast-glycolytic compared t

SUBMITTER: Srikuea R 

PROVIDER: S-EPMC7237670 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature