Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.

ABSTRACT: Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7237762 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature