Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.

ABSTRACT: Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signals. We hypothesized the existence of a dedicated mechanism that detects and removes mutant cells that missense the signal and therefore hyperproliferate and hypersecrete with potential to disrupt organismal homeostasis. In this mechanism, hypersecreting cells are preferentially eliminated by autoreactive T cells at the cost of a fragility to autoimmune disease. The "autoimmune surveillance of hypersecreting mutants" (ASHM) hypothesis predicts the presence of autoreactive T cells in healthy indiv

SUBMITTER: Korem Kohanim Y 

PROVIDER: S-EPMC7237888 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature