Clinical trials using molecular stratification of pediatric brain tumors.

ABSTRACT: Brain cancer is now the leading cause of cancer death in children and adolescents, surpassing leukemia. The heterogeneity and invasiveness of pediatric brain tumors have historically made them difficult to treat. Although surgical intervention and standard of care therapies such as radiation and chemotherapy have improved the outlook for those affected, results are often transient and lend themselves to tumor recurrence or resistance. There also still exists a subset of brain tumors which remain unresponsive to treatment altogether. Therefore, there is great need for new therapeutic approaches. With the recent advent of molecularly-driven technologies, many of these complex tumors can now be classified by integrating molecular profiling data with clinical information such as demographics a

SUBMITTER: Hanz SZ 

PROVIDER: S-EPMC7237976 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature