Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects.

ABSTRACT: The purpose of this study was to perform population pharmacokinetic (PPK) analysis of tiropramide in healthy Korean subjects, as well as to investigate the possible effects of various covariates on pharmacokinetic (PK) parameters of tiropramide. Although tiropramide is commonly used in digestive system-related diseases as an antispasmodic, PPK reporting and factors affecting PKs are not clearly reported. Thus, this study for healthy subjects is very significant because it could find new covariates in patients that had not been reported before or predict PPK for patients in the clinic by establishing PPK in healthy adults. By using Phoenix NLME, PK, demographic, and genetic data (collected to explain PK diversity of tiropramide in population) analyses were performed. As a basic model, a one

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC7238185 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature